A new study from the University of Washington suggests that one of the main causes of infertility and infertility-related disorders is a lack of reproductive function.
The study, which was published online in the journal Reproductive Biology and Biomedicine, examined a subset of the world’s 1.3 billion population, looking at a wide range of reproductive health problems from reproductive disorders to infertility.
The researchers found that infertility-associated conditions such as cysts, infertility-causing disorders, and pre-ovulatory infertility (POH) were more prevalent among women with low reproductive function than among women who have normal reproductive function, indicating that a genetic predisposition may be the underlying cause of many infertility-linked disorders.
In the study, they found that the genetic basis for these conditions is not just the cause of the infertility, but also the mechanism of the condition itself.
The authors believe this could help us to better understand how genetic differences are linked to the development of many other infertility-specific conditions, and how we can prevent the emergence of these conditions in the future.
“Many of these diseases have a genetic component, and it’s important that we understand how these diseases develop,” said study lead author Rachel N. Pender, a UW professor of biological sciences.
“It’s important to have a greater understanding of the genes that are involved, and also the genetic variations that are associated with the genetic disease.”
A few years ago, Pender co-authored a similar study on women with reproductive disorders and infertility, which found that these disorders and disorders associated with low fertility were most common in women who had inherited mutations in the CRISPR-Cas9 gene, the gene that encodes Cas9, the molecular mechanism that encases DNA from a bacterium that is used in CRISP.
“Cas9 encodes DNA from the bacterium Bacillus subtilis, which is a major producer of the CRPS-1 gene,” Pender said.
“CRPS-2 and CRPS3 are mutations in Cas9 that cause a deficiency in Cas8.”
In addition, the researchers found a number of genetic variants that were found to affect the CRP-1 protein.
They also found that women with a high CRP level had higher levels of certain mutations in CRP gene variants associated with infertility.
Pending further research, the authors hope that these findings will help researchers to identify genetic factors that might explain the development and progression of many of the disorders that affect women with fertility disorders, such as POH.
They hope that their research will lead to new therapies to improve the health of women with infertility-induced disorders, which can include infertility, POH, and cysts.
“We need to develop new drugs to improve reproductive function,” Penders said.
The UW researchers found, however, that these diseases are also more prevalent in women with normal reproductive health.
For example, they identified the same genetic variants associated to infertility in women whose reproductive health was relatively healthy compared to those who were in the highest genetic risk group.
For the majority of women in the study group, infertility was not the underlying reason for their infertility.
In addition to looking at genetics, Penders also looked at the effect of genetics on the development, progression, and treatment of reproductive disorders.
“Our study suggests that it may be more important to target specific genetic variants to treat the disease rather than the disease itself,” Ponder said.